Disulfide bonds are critical for stabilizing cell division, cell envelope biogenesis, and antibiotic resistance proteins in mycobacteria

ABSTRACT Mycobacteria, including Mycobacterium tuberculosis—the etiological agent of tuberculosis—possess a unique and impermeable cell envelope that is critical for survival and antibiotic resistance. The assembly and maintenance of this envelope depend on properly folded proteins, yet the role of...

Full description

Bibliographic Details

Published in:	mBio
Main Authors:	Adrian Mejia-Santana, Rebecca Collins, Emma H. Doud, Cristina Landeta
Format:	Article
Language:	English
Published:	American Society for Microbiology 2025-09-01
Subjects:	disulfide bonds oxidative protein folding DsbA VKOR substrates essential proteins
Online Access:	https://journals.asm.org/doi/10.1128/mbio.01083-25