BCL9/9L-β-catenin Signaling is Associated With Poor Outcome in Colorectal Cancer

BCL9/9L proteins enhance the transcriptional output of the β-catenin/TCF transcriptional complex and contribute critically to upholding the high WNT signaling level required for stemness maintenance in the intestinal epithelium. Here we show that a BCL9/9L-dependent gene signature derived from indep...

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發表在:	EBioMedicine
Main Authors:	Andreas E. Moor, Pascale Anderle, Claudio Cantù, Patrick Rodriguez, Norbert Wiedemann, Frédérique Baruthio, Jürgen Deka, Sylvie André, Tomas Valenta, Matthias B. Moor, Balázs Győrffy, David Barras, Mauro Delorenzi, Konrad Basler, Michel Aguet
格式:	Article
語言:	英语
出版:	Elsevier 2015-12-01
主題:	WNT signaling BCL9/9L-β-catenin Cancer stem cells Colorectal cancer subtypes Patient outcome
在線閱讀:	http://www.sciencedirect.com/science/article/pii/S2352396415301894