Unraveling the Hippo pathway: YAP/TAZ as central players in cancer metastasis and drug resistance

In regulating cellular plasticity, epithelial to mesenchymal transition (EMT), and tumor progression across a broad range of cancer types, the Hippo signaling pathway depends on YAP (Yes-associated protein) and TAZ (transcriptional coactivator with PDZ binding motif) as core effectors. This pathway...

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Bibliographic Details

Published in:	EXCLI Journal : Experimental and Clinical Sciences
Main Author:	Nehmat Ghaboura
Format:	Article
Language:	English
Published:	IfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmund 2025-06-01
Subjects:	EMT metastasis Hippo signaling YAP/TAZ TGF-β tumor aggressiveness
Online Access:	https://www.excli.de/excli/article/view/8351