Structural basis of a redox-dependent conformational switch that regulates the stress kinase p38α

Abstract Many functional aspects of the protein kinase p38α have been illustrated by more than three hundred structures determined in the presence of reducing agents. These structures correspond to free forms and complexes with activators, substrates, and inhibitors. Here we report the conformation...

وصف كامل

التفاصيل البيبلوغرافية
الحاوية / القاعدة:Nature Communications
المؤلفون الرئيسيون: Joan Pous, Blazej Baginski, Pau Martin-Malpartida, Lorena González, Margherita Scarpa, Eric Aragon, Lidia Ruiz, Rebeca A. Mees, Javier Iglesias-Fernández, Modesto Orozco, Angel R. Nebreda, Maria J. Macias
التنسيق: مقال
اللغة:الإنجليزية
منشور في: Nature Portfolio 2023-12-01
الوصول للمادة أونلاين:https://doi.org/10.1038/s41467-023-43763-5