SIRT1: A likely key for future therapeutic strategies for pain management

Sirtuin 1 (SIRT1), a NAD+ -dependent histone deacetylase, plays a crucial role in mitigating oxidative stress, regulating inflammation, and maintaining mitochondrial function. Reduced SIRT1 activity has been linked to elevated pro-inflammatory cytokines, mitochondrial dysfunction, and chronic pain,...

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Bibliographic Details

Published in:	Pharmacological Research
Main Authors:	Sara Ilari, Saverio Nucera, Lucia Carmela Passacatini, Rosamaria Caminiti, Valeria Mazza, Roberta Macrì, Maria Serra, Federica Scarano, Valentina Malafoglia, Ernesto Palma, Francesca Oppedisano, Jessica Maiuolo, Carlo Tomino, Vincenzo Mollace, Carolina Muscoli
Format:	Article
Language:	English
Published:	Elsevier 2025-03-01
Subjects:	Inflammation sirtuin 1 (SIRT1) Natural antioxidants Polyphenolic fraction of bergamot (BPF) Oxidative stress
Online Access:	http://www.sciencedirect.com/science/article/pii/S1043661825000957