Targeted Degradation of Class 1 HDACs With PROTACs is Highly Effective at Inducing DLBCL Cell Death

ABSTRACT Despite the good options for the management of Diffuse large B‐cell lymphoma (DLBCL), a significant percentage of patients either do not respond to current treatments or relapse after a short time. Thus, a wider palette of targeted therapeutic strategies is needed. Histone deacetylases (HDA...

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Bibliographic Details

Published in:	eJHaem
Main Authors:	Abdullah Alraddadi, Joshua P. Smalley, Wael Alzahrani, Anes Saleh, Fares Al‐Mansour, Buwei He, Thong H. Cao, Sandrine Jayne, Martin Dyer, James T. Hodgkinson, Donald J. L. Jones, Shaun M. Cowley, Salvador Macip
Format:	Article
Language:	English
Published:	Wiley 2025-08-01
Subjects:	apoptosis DLBCL HDAC HDAC inhibitors PROTAC
Online Access:	https://doi.org/10.1002/jha2.70127