Impact of genetically predicted characterization of mitochondrial DNA quantity and quality on osteoarthritis

Background: Existing studies have indicated that mitochondrial dysfunction may contribute to osteoarthritis (OA) development. However, the causal association between mitochondrial DNA (mtDNA) characterization and OA has not been extensively explored.Methods: Two-sample Mendelian randomization was pe...

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Bibliographic Details

Published in:	Frontiers in Genetics
Main Authors:	Houpu Liu, Bingyue Cai, Ruicheng Gong, Ye Yang, Jing Wang, Dan Zhou, Min Yu, Yingjun Li
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-02-01
Subjects:	mitochondrial heteroplasmy mitochondrial abundance osteoarthritis mendelian randomization knee OA (KOA)
Online Access:	https://www.frontiersin.org/articles/10.3389/fgene.2023.1130411/full