MMP14 from BM-MSCs facilitates progression and Ara-C resistance in acute myeloid leukemia via the JAK/STAT pathway

Abstract Growing evidence underscores the pivotal impact of crosstalk between leukemic stem cells (LSCs) and mesenchymal stromal cells (MSCs) within their niche on leukemia initiation, progression, and therapy response. Although MMP14 plays an important role in inflammation and cancer, the regulatio...

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出版年:	Experimental Hematology & Oncology
主要な著者:	Jinxian Wu, Xinqi Li, Yin Liu, Guopeng Chen, Ruihang Li, Hongqiang Jiang, Wanyue Yin, Xiqin Tong, Rui Cao, Xianwang Wang, Xiaoyan Liu, Fuling Zhou
フォーマット:	論文
言語:	英語
出版事項:	BMC 2025-03-01
主題:	Acute myeloid leukemia Mesenchymal stromal cells MMP14 JAK/STAT pathway PGE2
オンライン･アクセス:	https://doi.org/10.1186/s40164-025-00635-6