A dexamethasone prodrug reduces the renal macrophage response and provides enhanced resolution of established murine lupus nephritis.

We evaluated the ability of a macromolecular prodrug of dexamethasone (P-Dex) to treat lupus nephritis in (NZB × NZW)F1 mice. We also explored the mechanism underlying the anti-inflammatory effects of this prodrug. P-Dex eliminated albuminuria in most (NZB × NZW)F1 mice. Furthermore, P-Dex reduced t...

وصف كامل

التفاصيل البيبلوغرافية

الحاوية / القاعدة:	PLoS ONE
المؤلفون الرئيسيون:	Fang Yuan, Dana E Tabor, Richard K Nelson, Hongjiang Yuan, Yijia Zhang, Jenny Nuxoll, Kimberly K Bynoté, Subodh M Lele, Dong Wang, Karen A Gould
التنسيق:	مقال
اللغة:	الإنجليزية
منشور في:	Public Library of Science (PLoS) 2013-01-01
الوصول للمادة أونلاين:	http://europepmc.org/articles/PMC3842961?pdf=render