Targeting cardiac beta-adrenergic signaling via GRK2 inhibition for heart failure therapy

Cardiac cells, like those of the other tissues, undergo regulation through membrane-bound proteins known as G protein-coupled receptors (GPCRs). β-adrenergic receptors (βARs) are key GPCRs expressed on cardiomyocytes and their role is crucial in cardiac physiology since they regulate inotropic and...

Full description

Bibliographic Details

Published in:	Frontiers in Physiology
Main Authors:	Alessandro eCannavo, Daniela eLiccardo, Walter J. Koch
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2013-09-01
Subjects:	G-Protein-Coupled Receptor Kinase 2 Heart Failure G-protein coupled receptors Beta blockers Beta adrenergic system
Online Access:	http://journal.frontiersin.org/Journal/10.3389/fphys.2013.00264/full