Potent anti-Toxoplasma gondii activity of 4-chlorophenylthioacetone-derived thiosemicarbazones: Involvement of CCR2 and CCR5 receptors and 5-lipoxygenase in the mode of action

Toxoplasmosis is a disease requiring therapeutic innovation, and thiosemicarbazones with antimicrobial activity are candidates to control Toxoplasma gondii infection. Here, the anti-T. gondii activities of (E)-2-(1-(4-chlorophenylthio)propan-2-ylidene)-hydrazinecarbothioamides (Ca and Cb) were inves...

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Bibliographic Details

Published in:	Medicine in Drug Discovery
Main Authors:	Rayane Aparecida Nonato Rabelo, Diego Rodney Rodrigues de Assis, Alexandre Almeida Oliveira, César Luís Nascimento Barbosa, Rafaela das Dores Pereira, Ricardo Wagner de Almeida Vitor, Wiliam César Bento Régis, Mauro Martins Teixeira, Heloísa Beraldo, Fabiana Simão Machado
Format:	Article
Language:	English
Published:	Elsevier 2023-06-01
Subjects:	Toxoplasma gondii Toxoplasmose Thiosemicarbazones Macrophages Immune response
Online Access:	http://www.sciencedirect.com/science/article/pii/S2590098623000076