Borosilicate bioactive glass synergizing low-dose antibiotic loaded implants to combat bacteria through ATP disruption and oxidative stress to sequentially achieve osseointegration

Bone infection is a catastrophe in clinical orthopedics. Despite being the standard therapy for osteomyelitis, antibiotic-loaded polymethyl methacrylate (PMMA) cement has low efficiency against bacteria in biofilms. Furthermore, high-dose antibiotic-loaded implants carry risks of bacterial resistanc...

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Bibliographic Details

Published in:	Bioactive Materials
Main Authors:	Mengke Fan, Youliang Ren, Yanbin Zhu, Hao Zhang, Shuaijie Li, Chunyu Liu, Hongzhi Lv, Lei Chu, Zhiyong Hou, Yingze Zhang, Haobo Pan, Xu Cui, Wei Chen
Format:	Article
Language:	English
Published:	KeAi Communications Co., Ltd. 2025-02-01
Subjects:	Staphylococcus aureus Biofilm Osteomyelitis Borosilicate bioactive glass Polymethyl methacrylate
Online Access:	http://www.sciencedirect.com/science/article/pii/S2452199X24004535