A novel hybrid approach to overcome defects of CE-SELEX and cell-SELEX in developing aptamers against aspartate β-hydroxylase

Background and purpose: Aptamers, a new category of molecular probes, are overthrowing antibodies in molecular diagnostics. However, there are serious problems with using aptamers for this application including poor or non-specific binding in vivo conditions. Systematic evolution of aptamers is achi...

Full description

Bibliographic Details

Published in:	Research in Pharmaceutical Sciences
Main Authors:	Hadi Bakhtiari, Hamed Naghoosi, Sina Sattari, Mahmoud Vahidi, Mehdi Shakouri Khomartash, Ali Faridfar, Mohsen Rajaeinejad, Mohsen Nikandish
Format:	Article
Language:	English
Published:	Wolters Kluwer Medknow Publications 2025-01-01
Subjects:	aptamers aspartate β-hydroxylase capillary electrophoresis high-throughput nucleotide sequencing selex aptamer technique
Online Access:	https://journals.lww.com/10.4103/RPS.RPS_134_23