Sex-dependent effects of a high-fat diet on the hypothalamic response in mice

Abstract Sex differences in rodent models of diet-induced obesity are still poorly documented, particularly regarding how central mechanisms vary between sexes in response to an obesogenic diet. Here, we wanted to determine whether obese phenotype and hypothalamic response to a high-fat diet (HFD) d...

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Bibliographic Details

Published in:	Biology of Sex Differences
Main Authors:	Virginie Dreux, Candice Lefebvre, Charles-Edward Breemeersch, Colin Salaün, Christine Bôle-Feysot, Charlène Guérin, Pierre Déchelotte, Alexis Goichon, Moïse Coëffier, Ludovic Langlois
Format:	Article
Language:	English
Published:	BMC 2025-02-01
Subjects:	Obesity High fat diet Hypothalamus Arcuate nucleus Neuroinflammation Microglia
Online Access:	https://doi.org/10.1186/s13293-025-00699-3