Leucine alleviates cytokine storm syndrome by regulating macrophage polarization via the mTORC1/LXRα signaling pathway

Cytokine storms are associated with severe pathological damage and death in some diseases. Excessive activation of M1 macrophages and the subsequent secretion of pro-inflammatory cytokines are a major cause of cytokine storms. Therefore, promoting the polarization of M2 macrophages to restore immune...

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Bibliographic Details

Published in:	eLife
Main Authors:	Hui Yan, Yao Liu, Xipeng Li, Bing Yu, Jun He, Xiangbing Mao, Jie Yu, Zhiqing Huang, Yuheng Luo, Junqiu Luo, Aimin Wu, Daiwen Chen
Format:	Article
Language:	English
Published:	eLife Sciences Publications Ltd 2024-03-01
Subjects:	c57bl6 BMDM macrophages
Online Access:	https://elifesciences.org/articles/89750