Surveying the repair of ancient DNA from bones via high-throughput sequencing

DNA damage in the form of abasic sites, chemically altered nucleotides, and strand fragmentation is the foremost limitation in obtaining genetic information from many ancient samples. Upon cell death, DNA continues to endure various chemical attacks such as hydrolysis and oxidation, but repair pathw...

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Bibliographic Details

Published in:	BioTechniques
Main Authors:	Nathalie Mouttham, Jennifer Klunk, Melanie Kuch, Ron Fourney, Hendrik Poinar
Format:	Article
Language:	English
Published:	Taylor & Francis Group 2015-07-01
Subjects:	ancient DNA DNA damage DNA repair high-throughput sequencing
Online Access:	https://www.future-science.com/doi/10.2144/000114307