Angiotensin II induces endothelial dysfunction and vascular remodeling by downregulating TRPV4 channels

Angiotensin II (Ang II) is a potent vasoconstrictor of vascular smooth muscle cells (VSMC) and is implicated in hypertension, but it's role in the regulation of endothelial function is not well known. We and others have previously shown that mechanically activated ion channel, Transient Recepto...

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Bibliographic Details

Published in:	Journal of Molecular and Cellular Cardiology Plus
Main Authors:	Narendra Babu Kondapalli, Venkatesh Katari, Kesha Dalal, Sailaja Paruchuri, Charles K. Thodeti
Format:	Article
Language:	English
Published:	Elsevier 2023-12-01
Subjects:	Angiotensin II Ca2+ Endothelial cells eNOS TRPV4 Vascular remodeling
Online Access:	http://www.sciencedirect.com/science/article/pii/S2772976123000259