Xrcc5/KU80 is not required for the survival or activation of prophase-arrested oocytes in primordial follicles

IntroductionThe non-growing, meiotically-arrested oocytes housed within primordial follicles are exquisitely sensitive to genotoxic insults from endogenous and exogenous sources. Even a single DNA double-strand break (DSB) can trigger oocyte apoptosis, which can lead to accelerated depletion of the...

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Bibliographic Details

Published in:	Frontiers in Endocrinology
Main Authors:	Natasha D. Ratnayaka-Gamage, Lauren R. Alesi, Nadeen Zerafa, Jessica M. Stringer, Karla J. Hutt
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-10-01
Subjects:	DNA repair DNA damage oocytes non-homologous end joining fertility
Online Access:	https://www.frontiersin.org/articles/10.3389/fendo.2023.1268009/full