Adenoviral-mediated expression of G2019S LRRK2 induces striatal pathology in a kinase-dependent manner in a rat model of Parkinson's disease

Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene cause late-onset, autosomal dominant Parkinson's disease (PD). LRRK2 contains functional GTPase and kinase domains. The most common G2019S mutation enhances the kinase activity of LRRK2 in vitro whereas G2019S LRRK2 expression in cultur...

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發表在:	Neurobiology of Disease
Main Authors:	Elpida Tsika, An Phu Tran Nguyen, Julien Dusonchet, Philippe Colin, Bernard L. Schneider, Darren J. Moore
格式:	Article
語言:	英语
出版:	Elsevier 2015-05-01
主題:	LRRK2 Kinase Parkinsonism Parkinson's disease Adenovirus Neurodegeneration
在線閱讀:	http://www.sciencedirect.com/science/article/pii/S0969996115000534