Rosa26-LSL-dCas9-VPR: a versatile mouse model for tissue specific and simultaneous activation of multiple genes for drug discovery

Abstract Transgenic animals with increased or abrogated target gene expression are powerful tools for drug discovery research. Here, we developed a CRISPR-based Rosa26-LSL-dCas9-VPR mouse model for targeted induction of endogenous gene expression using different Adeno-associated virus (AAV) capsid v...

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Bibliographic Details

Published in:	Scientific Reports
Main Authors:	Dalia Pakalniškytė, Tanja Schönberger, Benjamin Strobel, Birgit Stierstorfer, Thorsten Lamla, Michael Schuler, Martin Lenter
Format:	Article
Language:	English
Published:	Nature Portfolio 2022-11-01
Online Access:	https://doi.org/10.1038/s41598-022-23127-7