Autophagy Controls the Kinetics and Extent of Mitochondrial Apoptosis by Regulating PUMA Levels

Macroautophagy is thought to protect against apoptosis; however, underlying mechanisms are poorly understood. We examined how autophagy affects canonical death receptor-induced mitochondrial outer membrane permeabilization (MOMP) and apoptosis. MOMP occurs at variable times in a population of cells,...

Full description

Bibliographic Details

Published in:	Cell Reports
Main Authors:	Jacqueline Thorburn, Zdenek Andrysik, Leah Staskiewicz, Jacob Gump, Paola Maycotte, Andrew Oberst, Douglas R. Green, Joaquín M. Espinosa, Andrew Thorburn
Format:	Article
Language:	English
Published:	Elsevier 2014-04-01
Online Access:	http://www.sciencedirect.com/science/article/pii/S2211124714001508