RNA binding by the glucocorticoid receptor attenuates dexamethasone-induced gene activation

Abstract The glucocorticoid receptor (GR) is a ligand-activated transcription factor that regulates a suite of genes through direct binding of GR to specific DNA promoter elements. GR also interacts with RNA, but the function of this RNA-binding activity remains elusive. Current models speculate tha...

وصف كامل

التفاصيل البيبلوغرافية
الحاوية / القاعدة:Scientific Reports
المؤلفون الرئيسيون: Nickolaus C. Lammer, Humza M. Ashraf, Daniella A. Ugay, Sabrina L. Spencer, Mary A. Allen, Robert T. Batey, Deborah S. Wuttke
التنسيق: مقال
اللغة:الإنجليزية
منشور في: Nature Portfolio 2023-06-01
الوصول للمادة أونلاين:https://doi.org/10.1038/s41598-023-35549-y