What Genetic Modifications of Source Pigs Are Essential and Sufficient for Cell, Tissue, and Organ Xenotransplantation?

Xenotransplantation of porcine organs has made remarkable progress towards clinical application. A key factor has been the generation of genetically multi-modified source pigs for xenotransplants, protected against immune rejection and coagulation dysregulation. While efficient gene editing tools an...

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Bibliographic Details

Published in:	Transplant International
Main Authors:	Asghar Ali, Mayuko Kurome, Barbara Kessler, Elisabeth Kemter, Eckhard Wolf
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2024-12-01
Subjects:	pig genetic modification xeno-antigens complement activation coagulation dysregulation
Online Access:	https://www.frontierspartnerships.org/articles/10.3389/ti.2024.13681/full