Preclinical development and characterisation of PP353, a formulation of linezolid for intradiscal administration

Abstract Introduction Bacterial infection of the intervertebral disc can lead to vertebral endplate edema known as Modic changes, with associated chronic low back pain. Oral antimicrobial therapy has shown efficacy but relies on prolonged dosing and may not be optimal in terms of patient outcome, si...

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Bibliographic Details

Published in:	JOR Spine
Main Authors:	Graham Hagger, Sarah Guest, Stephen Birchall, Alys Bradley, Charlie Brindley, David Corbett, Paul J. Cummings, Cristina Freire, James Harris, Andrew Wise, Melanie Wood, Lloyd G. Czaplewski
Format:	Article
Language:	English
Published:	Wiley 2024-12-01
Subjects:	intradiscal linezolid Modic pharmacokinetics vertebrogenic back pain
Online Access:	https://doi.org/10.1002/jsp2.70010