The conformational landscape of TRiC ring-opening and its underlying stepwise mechanism revealed by cryo-EM

The TRiC/CCT complex assists in the folding of approximately 10% of cytosolic proteins through an ATP-driven conformational cycle, playing a crucial role in maintaining protein homeostasis. Despite our understanding of ATP-driven TRiC ring closing and substrate folding, the process and mechanisms un...

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Bibliographic Details

Published in:	QRB Discovery
Main Authors:	Mingliang Jin, Yunxiang Zang, Huping Wang, Yao Cong
Format:	Article
Language:	English
Published:	Cambridge University Press 2025-01-01
Subjects:	Chaperonin cryo-EM conformational change TRiC ADP
Online Access:	https://www.cambridge.org/core/product/identifier/S2633289224000176/type/journal_article