Increased IKKϵ protein stability ensures efficient type I interferon responses in conditions of TBK1 deficiency

TBK1 and IKKϵ are related, crucial kinases in antiviral immune signaling pathways downstream of cytosolic nucleic acid receptors such as cGAS and RIG-I-like receptors. Upon activation, they phosphorylate the transcription factors IRF3 and IRF7 and thereby initiate the expression of type I interferon...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Julia Wegner, Charlotte Hunkler, Katrin Ciupka, Gunther Hartmann, Martin Schlee
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-03-01
Subjects:	innate immunity pathogens virus infection nucleic acid sensing cGAS TBK1
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2023.1073608/full