Construction of cancer- associated fibroblasts related risk signature based on single-cell RNA-seq and bulk RNA-seq data in bladder urothelial carcinoma

BackgroundThe ability of cancer-associated fibroblasts (CAFs) to encourage angiogenesis, tumor cell spread, and increase treatment resistance makes them pro-tumorigenic. We aimed to investigate the CAF signature in Bladder urothelial carcinoma (BLCA) and, for clinical application, to build a CAF-bas...

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Bibliographic Details

Published in:	Frontiers in Oncology
Main Authors:	Yunxun Liu, Jun Jian, Ye Zhang, Lei Wang, Xiuheng Liu, Zhiyuan Chen
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-04-01
Subjects:	cancer-associated fibroblasts bladder urothelial carcinoma tumor microenvironment immunotherapy single-cell RNA-seq prognosis
Online Access:	https://www.frontiersin.org/articles/10.3389/fonc.2023.1170893/full