Intratumoral microbial abundance and load influence the immune microenvironment of oral squamous cell carcinoma

ObjectiveThis study aimed to explore the characteristics intratumoral microbiome in oral squamous cell carcinoma, and elucidate the interplay between intratumoral microbial profiles (relative abundance/absolute load) and tumor-infiltrating lymphocytes markers (CD4+/CD8+/FOXP3) and PD-L1 in oral squa...

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Bibliographic Details

Published in:	Frontiers in Oncology
Main Authors:	Jiajun Fang, Mengna Wu, Hongyu Shen, Weijie Liu, Tonghan Zhang
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-09-01
Subjects:	oral squamous cell carcinoma intratumoral microbiome tumor infiltrating lymphocytes immune checkpoints immunotherapy
Online Access:	https://www.frontiersin.org/articles/10.3389/fonc.2025.1616928/full