Granzyme B + CD8 + T cells with terminal differentiated effector signature determine multiple sclerosis progression

Abstract Background Multiple sclerosis (MS) leads to demyelination and neurodegeneration with autoimmune responses in central nervous system. Patients begin with a relapsing–remitting (RR) course, and more than 80% of them may advance to secondary progressive MS (SPMS), which is characteristic for t...

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Bibliographic Details

Published in:	Journal of Neuroinflammation
Main Authors:	Ziyan Shi, Xiaofei Wang, Jiancheng Wang, Hongxi Chen, Qin Du, Yanlin Lang, Lingyao Kong, Wenqin Luo, Yuhan Qiu, Ying Zhang, Chen Li, Dingke Wen, Jie Yao, Xia Cheng, Linjun Cai, Xue Lin, Rui Wang, Zichao Mou, Shuangjie Li, Duanya Liu, Hong Zhou, Hongyu Zhou, Mu Yang
Format:	Article
Language:	English
Published:	BMC 2023-06-01
Subjects:	Multiple sclerosis Secondary progression Single-cell RNA sequencing CD8 + TEMRA cells GzmB Clonal expansion
Online Access:	https://doi.org/10.1186/s12974-023-02810-0