Pathophysiological conditions induced by SARS-CoV-2 infection reduce ACE2 expression in the lung

SARS-CoV-2 infection causes a variety of physiological responses in the lung, and understanding how the expression of SARS-CoV-2 receptor, angiotensin-converting enzyme 2 (ACE2), and its proteolytic activator, transmembrane serine protease 2 (TMPRSS2), are affected in patients with underlying diseas...

Full description

Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Yoko Miura, Hirotsugu Ohkubo, Akiko Nakano, Jane E. Bourke, Satoshi Kanazawa
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-11-01
Subjects:	angiotensin converting enzyme 2 (ACE2) idiopathic pulmonary fibrosis (IPF) SARS-CoV-2 precision-cut lung slices (PCLS) transmembrane protease serine 2 (TMPRSS2)
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2022.1028613/full