Targeting DKK1 enhances the antitumor activity of paclitaxel and alleviates chemotherapy-induced peripheral neuropathy in breast cancer

Abstract Chemotherapy in combination with immunotherapy has gradually shown substantial promise to increase T cell infiltration and antitumor efficacy. However, paclitaxel in combination with immune checkpoint inhibitor targeting PD-1/PD-L1 was only used to treat a small proportion of metastatic tri...

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Bibliographic Details

Published in:	Molecular Cancer
Main Authors:	Hong-Xiang Shi, Hang-Tian Tao, Jin-Jin He, Feng-Yi Zhu, Cui-Qing Xie, Yu-Na Cheng, Li-Li Hou, Hua Sun, Chang-Jiang Qin, Dong Fang, Song-Qiang Xie
Format:	Article
Language:	English
Published:	BMC 2024-07-01
Subjects:	Paclitaxel DKK1 EGFR Peripheral neuropathy Breast cancer
Online Access:	https://doi.org/10.1186/s12943-024-02067-y