Platform combining statistical modeling and patient-derived organoids to facilitate personalized treatment of colorectal carcinoma

Abstract Background We propose a new approach for designing personalized treatment for colorectal cancer (CRC) patients, by combining ex vivo organoid efficacy testing with mathematical modeling of the results. Methods The validated phenotypic approach called Therapeutically Guided Multidrug Optimiz...

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التفاصيل البيبلوغرافية

الحاوية / القاعدة:	Journal of Experimental & Clinical Cancer Research
المؤلفون الرئيسيون:	George M. Ramzy, Maxim Norkin, Thibaud Koessler, Lionel Voirol, Mathieu Tihy, Dina Hany, Thomas McKee, Frédéric Ris, Nicolas Buchs, Mylène Docquier, Christian Toso, Laura Rubbia-Brandt, Gaetan Bakalli, Stéphane Guerrier, Joerg Huelsken, Patrycja Nowak-Sliwinska
التنسيق:	مقال
اللغة:	الإنجليزية
منشور في:	BMC 2023-04-01
الموضوعات:	Drug-drug interaction Drug resistance Multidrug combination Organoid Phenotypic screen Synergy
الوصول للمادة أونلاين:	https://doi.org/10.1186/s13046-023-02650-z