Mouse SCNT ESCs Have Lower Somatic Mutation Load Than Syngeneic iPSCs

Ectopic expression of reprogramming factors has been widely adopted to reprogram somatic nucleus into a pluripotent state (induced pluripotent stem cells [iPSCs]). However, genetic aberrations such as somatic gene mutation in the resulting iPSCs have raised concerns regarding their clinical utility....

Full description

Bibliographic Details

Published in:	Stem Cell Reports
Main Authors:	Zhe Li, Hongxia Lu, Weifeng Yang, Jun Yong, Zhen-ning Zhang, Kun Zhang, Hongkui Deng, Yang Xu
Format:	Article
Language:	English
Published:	Elsevier 2014-04-01
Online Access:	http://www.sciencedirect.com/science/article/pii/S2213671114000575