Interplay between WNT/PI3K-mTOR axis and the microbiota in APC-driven colorectal carcinogenesis: data from a pilot study and possible implications for CRC prevention

Abstract Background Wnt/β-catenin signalling impairment accounts for 85% of colorectal cancers (CRCs), including sporadic and familial adenomatous polyposis (FAP) settings. An altered PI3K/mTOR pathway and gut microbiota also contribute to CRC carcinogenesis. We studied the interplay between the two...

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Bibliographic Details

Published in:	Journal of Translational Medicine
Main Authors:	Floriana Jessica Di Paola, Chiara Alquati, Gabriele Conti, Giulia Calafato, Silvia Turroni, Federica D’Amico, Claudio Ceccarelli, Francesco Buttitta, Alice Bernardi, Dajana Cuicchi, Gilberto Poggioli, Daniela Turchetti, Simona Ferrari, Renato Cannizzaro, Stefano Realdon, Patrizia Brigidi, Luigi Ricciardiello
Format:	Article
Language:	English
Published:	BMC 2024-07-01
Subjects:	Colorectal cancer Familial adenomatous polyposis Wnt/β-catenin PI3K/mTOR Microbiota
Online Access:	https://doi.org/10.1186/s12967-024-05305-5