Small protein blockers of human IL-6 receptor alpha inhibit proliferation and migration of cancer cells

Abstract Background Interleukin-6 (IL-6) is a multifunctional cytokine that controls the immune response, and its role has been described in the development of autoimmune diseases. Signaling via its cognate IL-6 receptor (IL-6R) complex is critical in tumor progression and, therefore, IL-6R represen...

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Bibliographic Details

Published in:	Cell Communication and Signaling
Main Authors:	Yaroslava Groza, Lukáš Lacina, Milan Kuchař, Leona Rašková Kafková, Kateřina Zachová, Olga Janoušková, Radim Osička, Jiří Černý, Hana Petroková, Joanna Maria Mierzwicka, Natalya Panova, Petr Kosztyu, Kristýna Sloupenská, Jan Malý, Jozef Škarda, Milan Raška, Karel Smetana, Petr Malý
Format:	Article
Language:	English
Published:	BMC 2024-05-01
Subjects:	IL-6 IL-6R blockers Cancer cell migration Migrastatics Malignant melanoma Pancreatic carcinoma
Online Access:	https://doi.org/10.1186/s12964-024-01630-w