Inhibition of IRP2-dependent reprogramming of iron metabolism suppresses tumor growth in colorectal cancer

Abstract Background Dysregulation of iron metabolism is implicated in malignant transformation, cancer progression, and therapeutic resistance. Here, we demonstrate that iron regulatory protein 2 (IRP2) preferentially regulates iron metabolism and promotes tumor growth in colorectal cancer (CRC). Me...

Full description

Bibliographic Details

Published in:	Cell Communication and Signaling
Main Authors:	Jieon Hwang, Areum Park, Chinwoo Kim, Chang Gon Kim, Jaesung Kwak, Byungil Kim, Hyunjin Shin, Minhee Ku, Jaemoon Yang, Ayoung Baek, Jiwon Choi, Hocheol Lim, Kyoung Tai No, Xianghua Zhao, Uyeong Choi, Tae Il Kim, Kyu-Sung Jeong, Hyuk Lee, Sang Joon Shin
Format:	Article
Language:	English
Published:	BMC 2024-08-01
Subjects:	Iron regulatory protein 2 Iron metabolism Autophagy Colorectal cancer
Online Access:	https://doi.org/10.1186/s12964-024-01769-6