Sarm1 Deletion, but Not WldS, Confers Lifelong Rescue in a Mouse Model of Severe Axonopathy

Studies with the WldS mutant mouse have shown that axon and synapse pathology in several models of neurodegenerative diseases are mechanistically related to injury-induced axon degeneration (Wallerian degeneration). Crucially, an absence of SARM1 delays Wallerian degeneration as robustly as WldS, bu...

وصف كامل

التفاصيل البيبلوغرافية
الحاوية / القاعدة:Cell Reports
المؤلفون الرئيسيون: Jonathan Gilley, Richard R. Ribchester, Michael P. Coleman
التنسيق: مقال
اللغة:الإنجليزية
منشور في: Elsevier 2017-10-01
الموضوعات:
Sarm1
WldS
axonopathy
synaptopathy
NMNAT2-deficient mice
aging
motor function
neuromuscular junction
disease model
neurodegeneration
الوصول للمادة أونلاين:http://www.sciencedirect.com/science/article/pii/S2211124717313025

الانترنت

http://www.sciencedirect.com/science/article/pii/S2211124717313025

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