Signal detection and safety analysis of three tyrosine kinase inhibitors for HER-2 positive breast cancer: a retrospective study based on the FAERS database

ObjectiveTo identify adverse event (ADE) signals of three tyrosine kinase inhibitors (TKIs) (Tucatinib, Lapatinib, and Neratinib) used for HER-2 positive breast cancer by utilizing the FAERS database, and to analyze their safety profiles to provide references for clinical risk management.MethodsData...

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Bibliographic Details

Published in:	Frontiers in Pharmacology
Main Authors:	Xiting Tang, Chengliang Wang, Yanwei Li, Jing Tang, Guoping Zhang, Li Chen
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-03-01
Subjects:	FAERS database tyrosine kinase inhibitors (TKIs) HER-2 positive breast cancer adverse event signals safety analysis disproportionality analysis (ROR, PRR)
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2025.1538881/full