HAX1, gene responsible for Kostmann syndrome, regulates gingival epithelial barrier function via intracellular trafficking of JAM1

BackgroundKostmann syndrome is an autosomal recessive disorder caused by a mutation of the hematopoietic cell-specific Lyn substrate 1 associated protein X-1 (HAX1) gene, and characterized by low number of neutrophils and increased susceptibility to infections. Additionally, Kostmann syndrome is kno...

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發表在:	Frontiers in Cell and Developmental Biology
Main Authors:	Keita Tanigaki, Tsukasa Tamamori, Naoko Sasaki, Risako Matsumura, Shunsuke Yamaga, Akito Sakanaka, Atsuo Amano, Michiya Matsusaki, Hiroki Takeuchi, Masae Kuboniwa
格式:	Article
語言:	英语
出版:	Frontiers Media S.A. 2025-08-01
主題:	HAX1 JAM1 Kostmann syndrome cisplatin periodontitis barrier
在線閱讀:	https://www.frontiersin.org/articles/10.3389/fcell.2025.1624718/full