Characterization and Applicability of a Bone Spheroid Model for the Evaluation of Cytocompatibility of Bone Substitutes

In vitro cell-based tests are an important preclinical step for the safety assessment of biomaterials and drugs. Three-dimensional cell culture models (3D) may improve the limitations of the usual 2D models, as they better simulate a physiological environment. This work describes the characterizatio...

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Bibliographic Details

Published in:	Applied Sciences
Main Authors:	Ana Carolina Batista Brochado, Daniela Costa Silva, Joice Correa da Silva, Adam Lowenstein, Vinicius Schott Gameiro, Elena Mavropoulos, Carlos F. Mourão, Gutemberg Gomes Alves
Format:	Article
Language:	English
Published:	MDPI AG 2023-01-01
Subjects:	cell culture bone substitute biomaterials osteoblasts
Online Access:	https://www.mdpi.com/2076-3417/13/3/1602