Higher incidence of delayed methotrexate clearance in pediatric acute lymphoblastic leukemia patients treated with imatinib

Background: Pediatric patients with Philadelphia chromosome positive (Ph+) or ABL-class fusion positive acute lymphoblastic leukemia (ALL) are currently treated with the tyrosine kinase inhibitor (TKI) imatinib added to a chemotherapy backbone that also contains several courses of high-dose methotre...

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Bibliographic Details

Published in:	EJC Paediatric Oncology
Main Authors:	Inge M. van der Sluis, Nikita D. van Dijk, Leiah J. Brigitha, Freya M. Steinhauer, Rob Pieters
Format:	Article
Language:	English
Published:	Elsevier 2023-12-01
Subjects:	Acute lymphoblastic leukemia Imatinib High-dose methotrexate Clearance Pediatric
Online Access:	http://www.sciencedirect.com/science/article/pii/S2772610X23001113