Systematic pharmacological screens uncover novel pathways involved in cerebral cavernous malformations

Abstract Cerebral cavernous malformations (CCMs) are vascular lesions in the central nervous system causing strokes and seizures which currently can only be treated through neurosurgery. The disease arises through changes in the regulatory networks of endothelial cells that must be comprehensively u...

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Bibliographic Details

Published in:	EMBO Molecular Medicine
Main Authors:	Cécile Otten, Jessica Knox, Gwénola Boulday, Mathias Eymery, Marta Haniszewski, Martin Neuenschwander, Silke Radetzki, Ingo Vogt, Kristina Hähn, Coralie De Luca, Cécile Cardoso, Sabri Hamad, Carla Igual Gil, Peter Roy, Corinne Albiges‐Rizo, Eva Faurobert, Jens P von Kries, Mónica Campillos, Elisabeth Tournier‐Lasserve, W Brent Derry, Salim Abdelilah‐Seyfried
Format:	Article
Language:	English
Published:	Springer Nature 2018-09-01
Subjects:	angiogenesis CCM ERK5 indirubin‐3‐monoxime KLF2
Online Access:	https://doi.org/10.15252/emmm.201809155