Optimization and Anti-Cancer Properties of Fluoromethylketones as Covalent Inhibitors for Ubiquitin C-Terminal Hydrolase L1

The deubiquitinating enzyme (DUB) UCHL1 is implicated in various disease states including neurodegenerative disease and cancer. However, there is a lack of quality probe molecules to gain a better understanding on UCHL1 biology. To this end a study was carried out to fully characterize and optimize...

詳細記述

書誌詳細

出版年:	Molecules
主要な著者:	Aaron D. Krabill, Hao Chen, Sajjad Hussain, Chad S. Hewitt, Ryan D. Imhoff, Christine S. Muli, Chittaranjan Das, Paul J. Galardy, Michael K. Wendt, Daniel P. Flaherty
フォーマット:	論文
言語:	英語
出版事項:	MDPI AG 2021-02-01
主題:	covalent inhibitors fluoromethylketones UCHL1 inhibitors deubiquitinases
オンライン･アクセス:	https://www.mdpi.com/1420-3049/26/5/1227