Altered expression of K13 disrupts DNA replication and repair in Plasmodium falciparum

Abstract Background Plasmodium falciparum exhibits resistance to the artemisinin component of the frontline antimalarial treatment Artemisinin-based Combination Therapy in South East Asia. Millions of lives will be at risk if artemisinin resistance (ART-R) spreads to Africa. Single non-synonymous mu...

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Bibliographic Details

Published in:	BMC Genomics
Main Authors:	Justin Gibbons, Katrina A. Button-Simons, Swamy R. Adapa, Suzanne Li, Maxwell Pietsch, Min Zhang, Xiangyun Liao, John H. Adams, Michael T. Ferdig, Rays H. Y. Jiang
Format:	Article
Language:	English
Published:	BMC 2018-11-01
Subjects:	Malaria Artemisinin K13 Drug-resistance
Online Access:	http://link.springer.com/article/10.1186/s12864-018-5207-7