1,3,4-oxadiazoles as inhibitors of the atypical member of the BET family bromodomain factor 3 from Trypanosoma cruzi (TcBDF3)

Chagas disease, caused by the protozoan parasite Trypanosoma cruzi, affects millions globally, with increasing urban cases outside of Latin America. Treatment is based on two compounds, namely, benznidazole (BZ) and nifurtimox, but chronic cases pose several challenges. Targeting lysine acetylation,...

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Bibliographic Details

Published in:	Frontiers in Microbiology
Main Authors:	Victoria L. Alonso, Andrea M. Escalante, Elvio Rodríguez Araya, Gianfranco Frattini, Luis E. Tavernelli, Diego M. Moreno, Ricardo L. E. Furlan, Esteban Serra
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2024-10-01
Subjects:	bromodomain Chagas disease tubulin acetylation cytoskeleton 1,3,4-oxadiazoles BET bromodomain
Online Access:	https://www.frontiersin.org/articles/10.3389/fmicb.2024.1465672/full