Activation of angiopoietin-1 signaling with engineering mesenchymal stem cells promoted efficient angiogenesis in diabetic wound healing

Abstract Background Vascular insufficiency is associated with the pathogenesis and therapeutic outcomes of diabetic foot ulcers (DFU). While mesenchymal stem cells (MSCs) hold potential for DFU treatment, further enhancement in promoting angiogenesis in the challenging DFU wounds is imperative. Meth...

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Bibliographic Details

Published in:	Stem Cell Research & Therapy
Main Authors:	Qiong Deng, Fangzhou Du, Shenzhen Pan, Yuchen Xia, Yuxin Zhu, Jingzhong Zhang, Chenglong Li, Shuang Yu
Format:	Article
Language:	English
Published:	BMC 2025-02-01
Subjects:	Mesenchymal stem cells Angiopoietin-1 Diabetic Wound Healing Angiogenesis Vascular leakage
Online Access:	https://doi.org/10.1186/s13287-025-04207-7