Role of FLCN Phosphorylation in Insulin‐Mediated mTORC1 Activation and Tumorigenesis

Abstract The amino acid‐stimulated Rag GTPase pathway is one of the main pathways that regulate mechanistic target of rapamycin complex 1 (mTORC1) activation and function, but little is known about the effects of growth factors on Rag GTPase‐mediated mTORC1 activation. Here, a highly conserved insul...

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Bibliographic Details

Published in:	Advanced Science
Main Authors:	Guoyan Wang, Lei Chen, Xinjian Lei, Senlin Qin, Huijun Geng, Yining Zheng, Chao Xia, Junhu Yao, Tong Meng, Lu Deng
Format:	Article
Language:	English
Published:	Wiley 2023-06-01
Subjects:	FLCN phosphorylation insulin mTORC1 tumorigenesis
Online Access:	https://doi.org/10.1002/advs.202206826