RETRACTED ARTICLE: Combination of alpha-synuclein immunotherapy with anti-inflammatory treatment in a transgenic mouse model of multiple system atrophy

Abstract Multiple system atrophy (MSA) is a fatal neurodegenerative disorder characterized by the pathological accumulation of alpha-synuclein (α-syn) in oligodendrocytes. Therapeutic efforts to stop or delay the progression of MSA have yielded suboptimal results in clinical trials, and there are no...

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Bibliographic Details
Published in:Acta Neuropathologica Communications
Main Authors: Elvira Valera, Brian Spencer, Jerel A. Fields, Ivy Trinh, Anthony Adame, Michael Mante, Edward Rockenstein, Paula Desplats, Eliezer Masliah
Format: Article
Language:English
Published: BMC 2017-01-01
Subjects:
Multiple system atrophy
Alpha-synuclein
Immunotherapy
Single-chain antibody
Lenalidomide
Neuroinflammation
Online Access:https://doi.org/10.1186/s40478-016-0409-1

Internet

https://doi.org/10.1186/s40478-016-0409-1

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