Inhibition of cancer-type amino acid transporter LAT1 suppresses B16-F10 melanoma metastasis in mouse models

Abstract Metastasis is the leading cause of mortality in cancer patients. L-type amino acid transporter 1 (LAT1, SLC7A5) is a Na+-independent neutral amino acid transporter highly expressed in various cancers to support their growth. Although high LAT1 expression is closely associated with cancer me...

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Bibliographic Details

Published in:	Scientific Reports
Main Authors:	Zitong Shi, Kazuko Kaneda-Nakashima, Ryuichi Ohgaki, Minhui Xu, Hiroki Okanishi, Hitoshi Endou, Shushi Nagamori, Yoshikatsu Kanai
Format:	Article
Language:	English
Published:	Nature Portfolio 2023-08-01
Online Access:	https://doi.org/10.1038/s41598-023-41096-3