APE1 mediates the occurrence and development of colitis-associated colorectal cancer through immunosuppressive tumor microenvironment

Objective To investigate the regulatory mechanism of apurnic/apyrimidinic endonuclease 1(APE1) in the transformation of chronic intestinal inflammation to colitis-associated colorectal cancer (CAC). Methods C64S mutant (APE1C64S) mice and APE1 wild type (APE1WT) mice were randomly divided into exper...

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Bibliographic Details

Published in:	陆军军医大学学报
Main Authors:	CHEN Tianyi, LI Chaofan, BAO Lingbo
Format:	Article
Language:	Chinese
Published:	Editorial Office of Journal of Army Medical University 2024-08-01
Subjects:	colitis-associated colorectal cancer inflammatory bowel diseases apurinic/apyrimidinic endonuclease 1 polymorphonuclear myeloid-derived suppressor cells colorectal cancer tumor microenvironment
Online Access:	https://aammt.tmmu.edu.cn/html/202404020.htm